منابع مشابه
Ground Reaction Forces in Patients with Unilateral Peripheral Arterial Disease
Peripheral arterial disease (PAD) is a manifestation of systemic atherosclerosis significantly reducing arterial blood to the lower extremities. Up to 12 million people in the USA suffer from PAD with claudication as the most common clinical manifestation. These claudicants have an inability to ambulate with a normal gait secondary to pain and fatigue of ischemic muscles. As the affected muscle...
متن کاملPeripheral arterial disease affects ground reaction forces during walking.
OBJECTIVE Claudication is the most common manifestation of peripheral arterial disease (PAD), producing significant ambulatory compromise. The gait of claudicating patients has been evaluated using primarily temporal and spatial parameters. With the present study, we used advanced biomechanical measures to further delineate the ambulatory impairment of claudicating patients. We hypothesized tha...
متن کاملPeripheral arterial disease affects the frequency response of ground reaction forces during walking.
BACKGROUND Walking is problematic for patients with peripheral arterial disease. The purpose of this study was to investigate the frequency domain of the ground reaction forces during walking to further elucidate the ambulatory impairment of these patients. METHODS Nineteen bilateral peripheral arterial disease patients and nineteen controls were included in this study. Subjects were matched ...
متن کاملThe human peripheral subunit-binding domain folds rapidly while overcoming repulsive Coulomb forces.
Peripheral subunit binding domains (PSBDs) are integral parts of large multienzyme complexes involved in carbohydrate metabolism. PSBDs facilitate shuttling of prosthetic groups between different catalytic subunits. Their protein surface is characterized by a high density of positive charges required for binding to subunits within the complex. Here, we investigated folding thermodynamics and ki...
متن کاملDynamic peripheral traction forces balance stable neurite tension in regenerating Aplysia bag cell neurons
Growth cones of elongating neurites exert force against the external environment, but little is known about the role of force in outgrowth or its relationship to the mechanical organization of neurons. We used traction force microscopy to examine patterns of force in growth cones of regenerating Aplysia bag cell neurons. We find that traction is highest in the peripheral actin-rich domain and i...
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ژورنال
عنوان ژورنال: Nature
سال: 2018
ISSN: 0028-0836,1476-4687
DOI: 10.1038/d41586-018-07210-6